Description
Highlights
Simplified method transfer
The unique, tunable gradient delay volume (GDV) and multiple thermostatting modes help refine separations to match the originating system. Users can tune the idle volume without replumbing or requalifying the system.
Flexible separations
Thermo Scientific SmartFlow pumping technology includes automatic compensation for changes in eluent compressibility to ensure flow and gradient precision, independent of eluent composition and backpressure. The pump can operate up to 700 bar and is available in binary, quaternary, and dual-gradient options.
Intelligent system tools
Two optional components are available to improve productivity, ensure compliance, and keep laboratories running smoothly. The Thermo Scientific Vanquish Solvent Monitor tracks solvent levels to prevent dry solvent channels and waste spills. Meanwhile, the touchscreen Vanquish User Interface provides visual monitoring of system status.
Versatility in analyte detection
A variety of detection options ensure you can collect the most information from your separation. Our portfolio includes diode array detection, near-universal charged aerosol detection, fluorescence detection, mass spectrometric detection and more.
Easy and reliable tool-free connections
The Vanquish Core HPLC system is fitted with Thermo Scientific Viper fingertight fittings, which support near-zero dead volume connections and enable sharper peaks and tool-free setup.
CDS software
The Vanquish Core HPLC system integrates with Thermo Scientific Chromeleon Chromatography Data System (CDS) with compliance tools, networking capabilities, automation, and data processing. We offer standard instrument integration (SII) packages to connect Thermo Scientific HPLC systems to other CDS and MS software programs.
System specifications
The table below provides an overview of the Vanquish Core HPLC system specifications for a standard setup. Not all specifications are listed. Your specifications may differ based on the components of your system. Find the specification sheets for the system components in the Component specifications, below.
| Category | Vanquish Core HPLC Systems |
| System pressure, maximum | 700 bar |
| Flow range | 0–10 mL/min |
| Pump options (default gradient delay volume) | Binary (400 µL)
Quaternary (679 µL) Isocratic Delay volume dependent on pump(s) selected |
| Biocompatible | No |
| pH range | 1–13, chloride concentration up to 0.1 mol/L |
| System design | Modular |
| Touchscreen user interface display compatible (optional) | Yes |
| Solvent monitoring system compatible (optional) | Yes |
| Customizable gradient delay volume to simplify method transfer | Yes, with method transfer kit |
| SmartInject technology for maximum injection precision and improved column lifetime | Yes |
| Injection volume range | Standard: 0.01-100 µL Optional: 0.01-1000 µL |
| Sample cooling | Yes, 4-40°C
Dependent on sampler selected |
| Sample capacity (standard) Based on standard 12 mm OD vials (≤ 1.5 mL) |
4 racks of 54 vials (≤ 1.5 mL) each, other rack formats available + capacity of 12 × 22.5 mm OD vials (≤ 10 mL) in the carousel |
| Sampler extension available (optional) | Yes, with Vanquish Charger |
| Column compartment thermostatting | Yes, 5-85°C Still air and forced air |
| Column compartment pre-heater | Active (optional) Passive |
| Column compartment post-column cooler | No |
| Detector choices | Vanquish Charged Aerosol Detector
Vanquish Diode Array Detector Vanquish Fluorescence Detector Vanquish Multiple Wavelength Detector Vanquish Variable Wavelength Detector Refractive Index Detector Mass Spectrometer |
Component specifications
Standard Vanquish Core HPLC systems are made up of the following components. Download the associated specifications sheet for more detail on each component.
| Vanquish Core Binary HPLC | Vanquish Core Quaternary HPLC | Vanquish Core Isocratic HPLC | |
| Pump
|
Vanquish Binary Pump C | Vanquish Quaternary Pump C/CN | Vanquish Isocratic Pump C |
| Autosampler
|
Vanquish Split Sampler C/CT | ||
| Extended sample capacity (optional)
|
Vanquish Charger (optional) | ||
| Column compartment
|
Vanquish Column Compartment C | ||
| Virtually zero dead volume system connections
|
Viper UHPLC Fittings Kits | ||
| Detectors
|
HPLC and UHPLC Detectors page | ||
| Optional components: Fraction Collector | Visit our Vanquish Fraction Collector FT page | ||